• 图片1

2-Methyl-5-nitroaniline

  • CasNo:99-55-8

Product Description

Good factory exports good 2-Methyl-5-nitroaniline 99-55-8

  • Molecular Formula: C7H8N2O2
  • Molecular Weight: 152.153
  • Appearance/Colour: yellow powder 
  • Melting Point: 104-107 °C 
  • Refractive Index: 1.6276 (estimate) 
  • Boiling Point: 329.4 °C at 760 mmHg 
  • PKA: 2.34±0.10(Predicted) 
  • Flash Point: 153 °C 
  • PSA: 71.84000 
  • Density: 1.269 g/cm3 
  • LogP: 2.58980 

2-Methyl-5-nitroaniline(Cas 99-55-8) Usage

Preparation

2-Methyl-5-nitrobenzenamine?in concentrated sulfuric acid nitration.

Definition

ChEBI: A C-nitro compound in which the nitro compound is meta to the amino group and para to the methyl group of o-toluidine.

Air & Water Reactions

Insoluble in water. 2-Methyl-5-nitroaniline is sensitive to moisture, light, or prolonged exposure to air.

Reactivity Profile

2-Methyl-5-nitroaniline is incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides and chloroformates.

Fire Hazard

Flash point data for 2-Methyl-5-nitroaniline are not available; however, 2-Methyl-5-nitroaniline is probably combustible.

Safety Profile

Confirmed carcinogen with experimental carcinogenic data. Moderately toxic by ingestion. Mutation data reported. Decomposes exothermically when heated to 150℃. When heated to decomposition it emits toxic fumes of NOx. See also NITRO COMPOUNDS OF AROMATIC HYDROCARBONS.

Carcinogenicity

There are no data available for evaluating carcinogenic risk to humans. When 5-nitro-o-toluidine was administered in a dietary feeding study to F344 rats (50 or 100 ppm) and B6C3F1 mice (1200 or 2300 ppm) of both sexes, hepatocellular carcinomas were produced in mice but not in rats.

Shipping

UN2660 Nitrotoluidines (mono), Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Acetylate the aniline, and the acetyl derivative is crystallised to constant melting point; then hydrolyse it with 70% H2SO4 and the free base is regenerated by treatment with NH3 [Bevan et al. J Chem Soc 4284 1956]. [Beilstein 12 H 844. 12 IV 1807.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, acid chlorides; acid anhydrides; chloroformates.

InChI:InChI=1/C7H8N2O2/c1-5-2-3-6(9(10)11)4-7(5)8/h2-4H,8H2,1H3

99-55-8 Relevant articles

Preparation and catalytic performance of active metal sintered membrane reactor anchored with Pt atoms

Ren, Xiaoliang,Wang, Shufang,Ding, Xiaoshu,Zhang, Dongsheng,Wang, Yanji

, p. 2848 - 2853 (2021/01/28)

In the chemical industry, reactors are t...

Synthesis, spectroscopic characterization, structural studies, thermal analysis and molecular docking of N-(2-methyl-5-nitrophenyl)-4-(pyridin-2-yl)pyrimidin-2-amine, a precursor for drug design against chronic myeloid leukemia

Arango-Daravi?a, Kevin,Kennedy, Alan R.,Moreno-Fuquen, Rodolfo

, p. 621 - 632 (2021/10/12)

The synthesis, crystal structure and spe...

A polyamine dendritic polymer-copper complex: A reusable catalyst for the additive-free amination of aryl bromides, and iodides

Avudaiappan,Palmurukan,Unnikrishnan,Sreekumar

, p. 1477 - 1484 (2020/02/05)

A porphyrin-initiated amine-functionaliz...

RAF-DEGRADING CONJUGATE COMPOUNDS

-

Paragraph 0209; 0229, (2018/11/22)

The present disclosure provides, inter a...

99-55-8 Process route

methanol
67-56-1

methanol

carbon monoxide
201230-82-2

carbon monoxide

2,4-dinitrotoluene
121-14-2

2,4-dinitrotoluene

2-methylcarbamoyl-4-nitro-toluene
63379-17-9

2-methylcarbamoyl-4-nitro-toluene

2,4-bis(methoxycarbonylamino)toluene
6935-99-5

2,4-bis(methoxycarbonylamino)toluene

2-methyl-5-nitroaniline
99-55-8

2-methyl-5-nitroaniline

Conditions
Conditions Yield
Pd(phen)2(OTf)2; In chlorobenzene; at 135 ℃; for 2h; under 45003.6 Torr; Yield given;
2,4-dinitrotoluene
121-14-2

2,4-dinitrotoluene

2-methyl-5-nitrophenol
5428-54-6

2-methyl-5-nitrophenol

4-Methyl-3-nitroanilin
119-32-4

4-Methyl-3-nitroanilin

2-methyl-5-nitroaniline
99-55-8

2-methyl-5-nitroaniline

Conditions
Conditions Yield
With hydrogen; In methanol; at 36 ℃; for 0.25h; under 760.051 Torr;

99-55-8 Upstream products

  • 121-14-2
    121-14-2

    2,4-dinitrotoluene

  • 95-80-7
    95-80-7

    4-methylbenzene-1,3-diamine

  • 120-66-1
    120-66-1

    N-(2-methylphenyl)acetamide

  • 136833-45-9
    136833-45-9

    2-nitro-4-amino-5-methylobenzoic acid

99-55-8 Downstream products

  • 21460-74-2
    21460-74-2

    2,2'-(5-Nitro-o-tolylimino)diethanol

  • 85142-57-0
    85142-57-0

    2-Methyl-5-nitrofumaranilic acid

  • 33238-32-3
    33238-32-3

    2-(2-methyl-5-nitrophenyl)isoindoline-1,3-dione

  • 16648-52-5
    16648-52-5

    ethyl (2-methyl-5-nitrophenyl)carbamate

*Product Name
CAS
Purity
Quantity
Company name
*Email
*Other Description
*Code
Fields with* are required
Submit