2-Methyl-5-nitroaniline
- CasNo:99-55-8
Product Description
Good factory exports good 2-Methyl-5-nitroaniline 99-55-8
- Molecular Formula: C7H8N2O2
- Molecular Weight: 152.153
- Appearance/Colour: yellow powder
- Melting Point: 104-107 °C
- Refractive Index: 1.6276 (estimate)
- Boiling Point: 329.4 °C at 760 mmHg
- PKA: 2.34±0.10(Predicted)
- Flash Point: 153 °C
- PSA: 71.84000
- Density: 1.269 g/cm3
- LogP: 2.58980
2-Methyl-5-nitroaniline(Cas 99-55-8) Usage
|
Preparation |
2-Methyl-5-nitrobenzenamine?in concentrated sulfuric acid nitration. |
|
Definition |
ChEBI: A C-nitro compound in which the nitro compound is meta to the amino group and para to the methyl group of o-toluidine. |
|
Air & Water Reactions |
Insoluble in water. 2-Methyl-5-nitroaniline is sensitive to moisture, light, or prolonged exposure to air. |
|
Reactivity Profile |
2-Methyl-5-nitroaniline is incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides and chloroformates. |
|
Fire Hazard |
Flash point data for 2-Methyl-5-nitroaniline are not available; however, 2-Methyl-5-nitroaniline is probably combustible. |
|
Safety Profile |
Confirmed carcinogen with experimental carcinogenic data. Moderately toxic by ingestion. Mutation data reported. Decomposes exothermically when heated to 150℃. When heated to decomposition it emits toxic fumes of NOx. See also NITRO COMPOUNDS OF AROMATIC HYDROCARBONS. |
|
Carcinogenicity |
There are no data available for evaluating carcinogenic risk to humans. When 5-nitro-o-toluidine was administered in a dietary feeding study to F344 rats (50 or 100 ppm) and B6C3F1 mice (1200 or 2300 ppm) of both sexes, hepatocellular carcinomas were produced in mice but not in rats. |
|
Shipping |
UN2660 Nitrotoluidines (mono), Hazard Class: 6.1; Labels: 6.1-Poisonous materials. |
|
Purification Methods |
Acetylate the aniline, and the acetyl derivative is crystallised to constant melting point; then hydrolyse it with 70% H2SO4 and the free base is regenerated by treatment with NH3 [Bevan et al. J Chem Soc 4284 1956]. [Beilstein 12 H 844. 12 IV 1807.] |
|
Incompatibilities |
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, acid chlorides; acid anhydrides; chloroformates. |
InChI:InChI=1/C7H8N2O2/c1-5-2-3-6(9(10)11)4-7(5)8/h2-4H,8H2,1H3
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The present disclosure provides, inter a...
99-55-8 Process route
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-
67-56-1
methanol
-
-
201230-82-2
carbon monoxide
-
-
121-14-2
2,4-dinitrotoluene
-
-
63379-17-9
2-methylcarbamoyl-4-nitro-toluene
-
-
6935-99-5
2,4-bis(methoxycarbonylamino)toluene
-
-
99-55-8
2-methyl-5-nitroaniline
| Conditions | Yield |
|---|---|
|
Pd(phen)2(OTf)2;
In
chlorobenzene;
at 135 ℃;
for 2h;
under 45003.6 Torr;
Yield given;
|
-
-
121-14-2
2,4-dinitrotoluene
-
-
5428-54-6
2-methyl-5-nitrophenol
-
-
119-32-4
4-Methyl-3-nitroanilin
-
-
99-55-8
2-methyl-5-nitroaniline
| Conditions | Yield |
|---|---|
|
With
hydrogen;
In
methanol;
at 36 ℃;
for 0.25h;
under 760.051 Torr;
|
99-55-8 Upstream products
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121-14-2
2,4-dinitrotoluene
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95-80-7
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120-66-1
N-(2-methylphenyl)acetamide
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136833-45-9
2-nitro-4-amino-5-methylobenzoic acid
99-55-8 Downstream products
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21460-74-2
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85142-57-0
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33238-32-3
2-(2-methyl-5-nitrophenyl)isoindoline-1,3-dione
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16648-52-5
ethyl (2-methyl-5-nitrophenyl)carbamate