N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide
- CasNo:871700-17-3
Product Description
Reputable factory supply N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide 871700-17-3 in bulk at low price
- Molecular Formula: C26H23FIN5O4
- Molecular Weight: 615.403
- Melting Point: 300-301 °C
- PKA: 14.76±0.70(Predicted)
- PSA： 110.62000
- Density: 1.743 g/cm3
- LogP: 4.66260
871700-17-3 Relevant articles
Method for synthesizing key intermediate of trametinib
-
Paragraph 0029, (2019/02/27)
The invention discloses a method for syn...
Method for synthesizing trametinib
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Paragraph 0033; 0034; 0037; 0041; 0045, (2019/02/25)
The invention discloses a method for syn...
SOLVATE FORM M OF TRAMETINIB DIMETHYL SULFOXIDE AND METHODS OF MAKING AND USING THEREOF
-
Paragraph 0093, (2015/06/10)
The present invention relates to a cryst...
5-AMINO-2,4,7-TRIOXO-3,4,7,8-TETRAHYDRO-2H-PYRIDO’2,3-D! PYRIMIDINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF CANCER
-
Page/Page column 149, (2008/06/13)
The present invention relates to a pyrim...
871700-17-3 Process route
-
![N-{3-[3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-ylamino]phenyl}acetamide](/upload/2026/6/f3164060f5344877996df6da70079067_f8acb11b-0501-4771-8883-7014fc3c0e7f.png)
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871700-25-3
N-{3-[3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-ylamino]phenyl}acetamide
-
-
871700-17-3
trametinib
| Conditions | Yield |
|---|---|
|
N-{3-[3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-ylamino]phenyl}acetamide;
With
sodium methylate;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 4h;
With
acetic acid;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 0.5h;
|
95%
|
|
With
sodium methylate;
|
95%
|
|
N-{3-[3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-ylamino]phenyl}acetamide;
With
sodium methylate;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 4h;
With
acetic acid;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 0.5h;
Product distribution / selectivity;
|
|
|
With
sodium methylate;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 4h;
Inert atmosphere;
|
4.75 g
|
-
![1-(3-aminophenyl)-3-cyclopropyl-5-{(2-fluoro-4-iodophenyl)amino}-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione](/upload/2026/6/f47e39f3332f4b8cbb287cfcacbb0dbd_a9d80bea-9a33-4110-8eef-7b738362b371.png)
-
1-(3-aminophenyl)-3-cyclopropyl-5-{(2-fluoro-4-iodophenyl)amino}-6,8-dimethylpyrido[4,3-d]pyrimidine-2,4,7(1H,3H,6H)-trione
-
-
871700-17-3
trametinib
| Conditions | Yield |
|---|---|
|
With
pyridine; acetic anhydride;
In
chloroform;
at 0 - 20 ℃;
for 2h;
|
44.8%
|
871700-17-3 Upstream products
-
871700-25-3
N-{3-[3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-ylamino]phenyl}acetamide
-
871700-37-7
N-(2-fluoro-4-iodophenyl)-N'-methylurea
-
1258884-52-4
2-fluoro-4-iodo-N-((methylimino)methylene)aniline
-
1258884-53-5
ethyl 2-(2-fluoro-4-iodophenylamino)-4-hydroxy-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylate