Afimoxifene
- CasNo:68392-35-8
Product Description
Quality products?make an important contribution to long-term revenue and profitability. Top Quality Chinese Manufacturer supply 68392-35-8 Afimoxifene
1.What is the Afimoxifene ?
(E/Z)-4-Hydroxy Tamoxifen is selective estrogen receptor modulator.
-
-
4584-46-7
(2-chloroethyl)dimethylamine hydrochloride
-
-
91221-46-4
1,1-bis(4-hydroxyphenyl)-2-phenyl-1-butene
-
-
68392-35-8,65213-48-1
4-hydroxytamoxifen
| Conditions | Yield |
|---|---|
|
1,1-bis(4-hydroxyphenyl)-2-phenyl-1-butene;
With
caesium carbonate;
In
N,N-dimethyl-formamide;
for 0.5h;
Reflux;
(2-chloroethyl)dimethylamine hydrochloride;
In
N,N-dimethyl-formamide;
at 120 ℃;
for 7h;
|
67%
|
|
1,1-bis(4-hydroxyphenyl)-2-phenyl-1-butene;
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 70 - 80 ℃;
for 0.166667h;
(2-chloroethyl)dimethylamine hydrochloride;
In
N,N-dimethyl-formamide;
for 1.75h;
|
30%
|
|
1,1-bis(4-hydroxyphenyl)-2-phenyl-1-butene;
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 0.166667h;
(2-chloroethyl)dimethylamine hydrochloride;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 5.5h;
|
13.6%
|
|
1,1-bis(4-hydroxyphenyl)-2-phenyl-1-butene;
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 0.166667h;
(2-chloroethyl)dimethylamine hydrochloride;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 5.5h;
|
13.6%
|
-
-
611-99-4
4,4'-Dihydroxybenzophenone
-
-
68392-35-8,65213-48-1
4-hydroxytamoxifen
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
2
steps
1.1: titanium tetrachloride; zinc / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere; Reflux; Darkness
2.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h / 70 - 80 °C
2.2: 1.75 h
With
titanium tetrachloride; caesium carbonate; zinc;
In
tetrahydrofuran; N,N-dimethyl-formamide;
1.1: McMurry reaction;
|
|
|
Multi-step reaction
with
2
steps
1.1: zinc; titanium tetrachloride / tetrahydrofuran / 12 h / -20 °C / Inert atmosphere; Reflux; Darkness
2.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / Reflux
2.2: 7 h / 120 °C
With
titanium tetrachloride; caesium carbonate; zinc;
In
tetrahydrofuran; N,N-dimethyl-formamide;
|
|
|
Multi-step reaction
with
2
steps
1.1: titanium tetrachloride; zinc / tetrahydrofuran / 2 h / -10 - 95 °C / Inert atmosphere
1.2: 2 h / 0 - 95 °C / Inert atmosphere; Darkness
2.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h / 80 °C
2.2: 5.5 h / 80 °C
With
titanium tetrachloride; caesium carbonate; zinc;
In
tetrahydrofuran; N,N-dimethyl-formamide;
|
|
|
Multi-step reaction
with
2
steps
1.1: zinc; titanium tetrachloride / tetrahydrofuran / 2 h / Inert atmosphere; Darkness
2.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h / 80 °C
2.2: 5.5 h / 80 °C
With
titanium tetrachloride; caesium carbonate; zinc;
In
tetrahydrofuran; N,N-dimethyl-formamide;
|
|
|
Multi-step reaction
with
2
steps
1: titanium tetrachloride; zinc / tetrahydrofuran / Inert atmosphere
2: caesium carbonate / N,N-dimethyl-formamide / Inert atmosphere
With
titanium tetrachloride; caesium carbonate; zinc;
In
tetrahydrofuran; N,N-dimethyl-formamide;
1: |McMurry Reaction;
|
2.What is the CAS number for Afimoxifene ?
The CAS number of Afimoxifene is 68392-35-8.
More information of Afimoxifene 68392-35-8 are:
|
CAS?Number |
68392-35-8 |
|
Density |
1.092 |
|
Melting Point |
135-144°C |
|
Boiling Point |
514.4±50.0 °C(Predicted) |
|
PSA |
32.70000 |
|
LogP |
5.70170 |
|
Pka |
9.38±0.15(Predicted) |
3.What are another words for Afimoxifene ?
Synonyms?for?Afimoxifene 68392-35-8:Phenol,4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]- (9CI); 4-OHT; 4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol;Afimoxifene; TamoGel
4.What is the molecular formula of Afimoxifene?
The chemical formula of ?Afimoxifene is?C26H29 N O2 which containing 26 Carbon atoms,29 Hydrogen atoms,1 Nitrogen atoms and 2 Oxygen atoms,and the molecular weight of??Afimoxifene?is 387.522.
5.What is Afimoxifene (68392-35-8) used for?
Afimoxifene, also known as (E/Z)-4-Hydroxy Tamoxifen, is a first-generation selective estrogen receptor modulator (SERM). It is an off-white solid with the brand name TamoGel, marketed by Ascend Therapeutics. As a SERM, Afimoxifene functions as an antagonist in breast cancer cells, while exhibiting estrogen-like activities in the uterus and bone.
InChI:InChI=1/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-
Relevant articles related to Afimoxifene:
|
Article |
Source |
|
ANTICANCER AGENT DELIVERY MOLECULE |
- , (2017/08/04) |
|
Targeting Cancer with PCPA-Drug Conjugates: LSD1 Inhibition-Triggered Release of 4-Hydroxytamoxifen |
Ota, Yosuke,Itoh, Yukihiro,Kaise, Asako,Ohta, Kiminori,Endo, Yasuyuki,Masuda, Mitsuharu,Sowa, Yoshihiro,Sakai, Toshiyuki,Suzuki, Takayoshi , p. 16115 - 16118 (2016/12/26) |
6.Buy Afimoxifene with the best price .
Shanghai Coupling Pharmaceutical R&D Co., Ltd. is a quality supplier of Afimoxifene. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Afimoxifene 68392-35-8.